October 4, 2021
Our recent article titled "Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe" by Jelly et al has been selected as the cover article for the most recent issue of the Journal of Biomedical Optics (Volume 26, Issue 9) published by SPIE.
The article investigates OCT performance towards distinguishing clinically relevant morphological features associated with small intestinal transplants. The current gold standard for screening small intestinal transplant rejection is endoscopic visual assessment and biopsy of suspicious lesions; however, these lesions are only superficially visualized by endoscopy. The sparse sampling associated with invasive biopsies provides a coarse subset of tissue health without depicting the true presence and extent of any pathology. Optical coherence tomography (OCT) presents a potential alternative approach with significant advantages over this traditional white-light endoscopy.
"The results presented in this article suggest that OCT imaging has significant potential to reveal morphological changes associated with IT rejection and to improve patient outcomes overall" said, Jelly.
For more information, the open-access report can be found here.