Angle-resolved low coherence interferometry (a/LCI) is a light scattering technique that combines the sub- cellular sensitivity of light scattering with the depth resolution of optical coherence tomography (OCT) that has shown promising results in detecting neoplasia in vivo by analyzing angular dependence of scattered light. Recently, we developed a 2D a/LCI system which has the capability of detecting the entire scattering field in two dimensions to provide more detailed information about the scattering structures. However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. We incorporated optical coherence tomography as a means to guide the a/LCI measurement which can provide a unique analysis of sample structure that cannot be attained using a single modality. We apply two dimensional a/LCI technology to ex vivo mouse model of progressive retinal degeneration/carcinogenesis to directly measure structural changes and develop quantitative biomarkers which could be used to predict the onset and progression of pathologies.