Spectroscopic Optical Coherence Tomography (SOCT)

We are developing methods that utilize spectroscopic optical coherence tomography (SOCT) to evaluate burn injuries and monitor changes in blood and tissue oxygenation. Evaluation of burn severity is a significant clinical problem as there are over 2 million burns reported each year in the US and clinical judgment still relies primarily on subjective visual inspection. Successful clinical management depends on an accurate assessment of the depth of the burn wound. Recently, we have applied SOCT in vivo in a mouse model to classify burned and adjacent healthy tissue achieving an accuracy of over 90%. We have also observed significant spectral differences that are correlated with the depth of the injury as determined by histopathology. Although the penetration depth may preclude use in clinically assessing deeper human tissues, we are also developing new techniques [multispectral multiple-scattering low-coherence interferometry (ms2/LCI)] to extend the imaging depth of conventional SOCT.

Current Personnel Working on SOCT:

Jason Maher
Yang Zhao

 
Collaborators:

Howard Levinson, MD